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The combination has not been studied across extended timeframes in humans
Notably, however, the unstable product flavan-3,3,4-triol ( 4 ) is converted mainly into the by-products epidihydroquercetin ( 9 ), dihydroquercetin ( 10 ) and quercetin ( 11) 13 , while the transformation into the coloured anthocyanidin has only been observed as a minor side reaction in vitro 11,12,13 or in vivo by engineered microorganisms 6,16
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Isoenzymes of HACL1 and HACL2 are shown to provide -oxidation of 3-methyl and 2-hydroxy long chain fatty acids, respectively, with HACL2 playing an important role in ceramide formation in the stomach (33)
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